Primary cilia utilize glycoprotein-dependent adhesion mechanisms to stabilize long-lasting cilia-cilia contacts
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چکیده
منابع مشابه
Primary cilia
The primary cilium was first so named by Sergei Sorokin in 1968.[1] Since the discovery of primary cilium in 1898 by Zimmerman, three major hypotheses for their function have been put forth. The first is that primary cilia are vestigial organelles inherited from an ancestor whose cells had motile cilia and now are of no purpose in multicellular organisms. The second is that they are involved in...
متن کاملPrimary cilia in bone.
lization. This independence of calcium and PGE 2 has been reported previously and suggests that there are multiple mechanisms by which bone cells sense their mechanical environment. These findings are currently in press in the Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. by oscillatory fluid flow via intracellular calcium mobilization and activation of ...
متن کاملHIF Stabilization Weakens Primary Cilia
Although solitary or sensory cilia are present in most cells of the body and their existence has been known since the sixties, very little is known about their functions. One suspected function is fluid flow sensing- physical bending of cilia produces an influx of Ca++, which can then result in a variety of activated signaling pathways. Defective cilia and ciliary-associated proteins have been ...
متن کاملPericentrin pivotal in primary cilia
Pericentrin pivotal in primary cilia he centrosome protein pericentrin acts as an anchor for primary cilia formation in human cells, according to a report by Jurczyk et al. (page 637). The finding further unites the centrosome and primary cilia, both of which are based around centri-oles, and both of which use pericentrin as an anchor for other proteins. The authors show that pericentrin is loc...
متن کاملEndothelial primary cilia inhibit atherosclerosis.
Primary cilia are microtubule-based structures present on most mammalian cells that are important for intercellular signaling. Cilia are present on a subset of endothelial cells where they project into the vessel lumen and are implicated as mechanical sensors of blood flow. To test the in vivo role of endothelial cilia, we conditionally deleted Ift88, a gene required for ciliogenesis, in endoth...
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ژورنال
عنوان ژورنال: Cilia
سال: 2012
ISSN: 2046-2530
DOI: 10.1186/2046-2530-1-3